Meningiomas are the commonest brain tumours in adults, but are rare in childhood. They occur twice as commonly in women as in men. The incidence of meningiomas has been increasing, but it is unclear whether this is genuine is merely a result of a wider availability of imaging technology.
The onset of meningioma-related symptoms in pregnancy or after hormone therapy is well-recognised. Also patients with previous cranial radiotherapy, for example treatment of childhood cancers, can also develop meningiomas in later life. However, most meningiomas occur without any known cause. Head injuries do not cause meningiomas, and neither does the use of mobile phones. Genetic alterations, such as mutations in NF2, SMO, AKT1, KLF4, TRAF7, TERT, ARID1A, CDKN2A and others have been identified in meningiomas , but the role of genes in the development of meningiomas is not yet fully understood.
Meningiomas are more common in families with tumour predisposition, such as those with familial mutations of NF2, NF1, PTCH, VHL, PTEN and others. There seems to be an increased probability of meningioma occurrence with increasing number of first-degree relatives with meningioma.
Written by Alireza Shoakazemi for BIMS